ChanClone™ Ion Channels

Genionics excels in the design of next generation cell line reagents to speed up ion channel screening. The proprietary ChanClone™ technology platform yields high-end ion channel cell lines to make drug discovery easier and faster.

We are aware of the needs associated with cell-based automated patch-clamping and put in an extra effort to deliver validated ion channel cells. Our primary objective is to fulfil all the compatibility requirements with the new robotic ion channel screening concepts. We understand the new patch-clamp concepts as hardware innovation and supply our cell products as assay application software.

Our ChanClone™ cell line repository provides a continuously expanding ion channel cell collection including polymorphic variants of ion channel genes. The use of our ChanClone™ reagents therefore opens a fast track for earliest ion channel allele screening. This enables our customers and partners to gain reliable and comprehensive information about ion channel cross-reactions at initial stages of drug discovery projects.

Polymorphic variants and mutations: Our ChanClone™ catalogue currently includes only reference ion channel targets for the sake of clarity. Please feel free to contact us if you wish our assistance with polymorphic variants or mutated ion channel alleles.

Product specifications:

• Target human cDNAs are fully sequenced
• High level expression of ion channels
• Approved mycoplasma testing
• Various cell types available: HEK 293, CHOK1, COS-7, ND7/23 etc.
• All cell line products validated
• Ready-to-use product format
• Stable current density over 30 passage cycles